Mywifesirrational
I however am very normal. Trust me.
1) You're taking more material out of the wheels. If you see no issues with that, then why don't manufactures drill out holes in all the gaps between spokes?
Probably to stop water and mud entering the rim and the extra cost of manufacturing, for very little weight loss.
But, yeah there'd be a structural issue with putting lots of holes in rims, one extra... would that make a difference if correctly drilled? is the area around the valve hole any different, thickness etc to the rast of the rim?